In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease

Figure 2

Brain MRI and [¹¹C]TMSX PET images from a 45-year-old healthy female (a and b, resp.) and of a 48-year-old female with SPMS (disease duration: 6 years, EDSS 7.5) (c and d, resp.). The images represent axial views from gadolinium-enhanced T1 images (a and c) and parametric [¹¹C]TMSX PET images with each voxel’s intensity representing the distribution volume (V_T, ml/cm3) value of the ligand fused with the T1 image (b and d). A pattern of increased [¹¹C]TMSX binding can be observed around the T1 hypointense lesions (white arrows) and within the mildly active plaque in the frontal white matter (yellow arrow) of the SPMS patient compared to the lower, homogeneous binding in the white matter of the healthy control. Figure reprinted with permission from Rissanen et al. (2013) [13].

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