Clinical Applications of Contrast-Enhanced Perfusion MRI Techniques in Gliomas: Recent Advances and Current Challenges

Table 1

Main perfusion parameters derived from DCE-MRI and DSC-MRI.

Parameters	Full name	Definition and meaning
DCE-MRI
	Volume transfer constant between blood plasma and EES	It describes the leakage rate of GBCAs from the blood plasma towards EES
	Extravascular extracellular volume fraction	Quantification of cellularity and necrosis in EES. together with characterize the microvascular permeability
	Blood plasma volume	Quantification of the volume of blood plasma
	Transfer constant from EES into blood plasma	It is determined by the equation /
DSC-MRI
CBV	Cerebral blood volume	The blood volume in a given region of brain tissue (unit, mL/100 g). It is calculated by integrating the area under the CC-TCC
CBF	Cerebral blood flow	The blood volume passing through a given region of brain tissue per unit of time (unit, mL/min/100 g)
MTT	Mean transit time	The average time in which blood passes through a given region of brain tissue (unit, s). It is estimated from the CC-TCC as width of the curve at half maximum height
PH	Peak height	The maximal drop of signal intensity from precontrast baseline during the first-pass bolus phase of GBCAs. It is correlated with CBV and reflects total blood volume
PSR	Percentage of signal intensity recovery	It reflects capillary permeability indirectly, providing information like
rCBV	Relative cerebral blood volume	Measurement of the relative lesion blood volume compared with that of contralateral white matter. It is proportional to the area under the CC-TCC, providing an estimate of MVD and angiogenesis
rCBF	Relative cerebral blood flow	Measurement of the relative lesion blood flow compared with that of contralateral white matter
	Leakage coefficient	Quantification of the degree of vascular permeability using algorithm method for leakage effect correction