|
| Study (year) (ref) | Group () | Average age (year) | Imaging modality (method or model; parameter analysis) | Indexes | Results | Limitations |
|
| Kickingereder et al. (2015) [60] | Grades II and III:
IDH (+) (59)
IDH (−) (14) | 49 | DSC-MRI (algorithm for leakage correction; histogram analysis) | rCBV | rCBV was significantly different between IDH mutation and wild-type tumors | Only including grades II and III tumors |
|
| Lee et al. (2015) [61] | HGG:
IDH (+) (16)
IDH (−) (36) | 50 | DSC-MRI (algorithm for leakage correction; histogram analysis) | nCBV | Significant difference of nCBV between IDH mutation and wildtype; higher heterogeneity in mutation tumor than the wild-type | Not including LGG. Not excluding influence of MGMT mutation |
|
| Tykocinski et al. (2012) [62] | GBM:
EGFRvIII (+) (30)
EGFRvIII (−) (102) | 61 | DSC-MRI (preload for leakage correction; ROI-based analysis) | rCBV | Strong correlation between rCBV and EGFRvIII status | Relative small sample size of EGFRvIII-positive tumors |
|
| Gupta et al. (2015) [63] | GBM:
EGFR (+) (44)
EGFR (−) (62)
EGFRvIII (+) (18)
EGFRvIII (−) (47) | 66 | DSC-MRI (γ-variate function for leakage correction; ROI-based analysis) | PSR
rPH
rCBV | Higher rCBV and lower PSR were associated with EGFR; higher rPH was related to EGFRvIII mutation | Pathologic sampling may not be consistent with ROI selection |
|
| Arevalo-Perez et al. (2015) [64] | GBM:
EGFRvIII (+) (24)
EGFRvIII (−) (58) | 66 | DCE-MRI (ETK model; histogram analysis) |
| Strong correlation between both parameters and EGFRvIII status; was better than for diagnosis | Not eliminating influence of other molecular mutations |
|
| Jung et al. (2013) [65] | GBM:
MGMT (+) (16)
MGMT (−) (9) | 52 | DSC-MRI (γ-variate function for leakage correction; ROI-based analysis) | nCBV | nCBV was higher in MGMT-negative tumors than in MGMT-positive tumors | Small sample size |
|
| Moon et al. (2012) [66] | HGG:
MGMT (+) (11)
MGMT (−) (13) | 51 | DSC-MRI (leakage effect uncorrected; ROI-based analysis) DTI | rCBV
ADC | No significant correlation between rCBV and MGMT | Small sample size; impact leakage effect of rCBV accuracy |
|
| Ahn et al. (2014) [67] | GBM:
MGMT (+) (16)
MGMT (−) (27) | 58 | DCE-MRI (TK model; ROI-based analysis); DTI |
ADC | Only was correlated with MGMT | Subjectivity of ROI-based method |
|
| Jenkinson et al. (2006) [68] | Grades II and III:
Codeletion (+) (19)
Codeletion (−) (18) | 44 | DSC-MRI (leakage effect uncorrected; ROI-based analysis) | rCBV | rCBV was associated with 1p/19q codeletion in oligodendroglioma | Subjectivity of ROI-based method; impact leakage effect of rCBV accuracy |
|
| Emblem et al. (2008) [42] | Grades II and III:
Codeletion (+) (11)
Codeletion (−) (11) | 52 | DSC-MRI (algorithm for leakage correction; histogram analysis) | rCBV | Histogram analysis of rCBV could differentiate 1p/19q genotype in astrocytic and oligodendroglial tumors | Small sample size; only the peak height of histogram distribution was assessed |
|
