|
| Study (year) (ref) | Group () | Average age (year) | Imaging modality (method or model; parameter analysis) | Indexes | Threshold (Sp%, Sn%) | limitations |
|
| Mangla et al. (2010) [150] | PsP (7)
TP (12) | 61 | DSC-MRI (algorithm for leakage effect correction; ROI-based analysis) | rCBV | Percentage change in rCBV for discrimination of PsP and TP (85.7%, 76.9%) | Retrospective; different treatment management; small sample size |
|
| Martínez-Martínez and Martínez-Bosch (2014) [151] | PsP (17)
TP (7) | 48 | DSR-MRI (leakage effect uncorrected; ROI-based analysis) | rCBV
rPSR
rPH | rPH = 1.37 (82.2%, 88%)
rCBV = 0.9 (100%, 100%)
rPSR = 99% (70.6%, 100%) | Retrospective; small sample size; impact of corticoid therapy on parameter evaluation; lack of histological confirmation |
|
| Prager et al. (2015) [152] | PsP (8)
TP (43) | 55 | DSC-MRI (γ-variate function for leakage correction; ROI-based analysis) | rCBV
rCBV | rCBV = 1.07 (75%, 100%)
rCBV = 1.74 (75%, 92.9%) | Retrospective; small sample size of PsP; MGMT in some patients may affect the perfusion parameters |
|
| Baek et al. (2012) [153] | PsP (37)
TP (42) | 49 | DSC-MRI (γ-variate function for leakage correction; histogram analysis) | nCBV | Percent change of skewness: 1.27% (79.2%, 85.7%)
Percent change of kurtosis: 14% (73.0%, 61.9%) | Different therapies in patients; results were obtained from only one observer |
|
| Tsien et al. (2010) [154] | PsP (13)
TP (14) | 52 | DSC-MRI (leakage effect uncorrected, parametric response map) | rCBV
rCBF | Not provided; patients with progressive had reduced rCBV | Leakage effect may underestimate rCBV value |
|
| Gahramanov et al. (2013) [155] | PsP (9)
TP (10) | N/A | DSC-MRI (ferumoxytol for leakage correction) | rCBV | rCBV = 1.5 (Sp%, Sn% not provided) | Lack of histopathologic confirmation; small sample size |
|
| Suh et al. (2013) [156] | PsP (36)
TP (43) | 50 | DCE-MRI (nonmodel fitting; histogram analysis) | AUCR
mAUCR | mAUCR = 0.31 (82.9%, 90.1%)
AUC50 = 0.19 (83.1%, 87.2%) | Lack of correlation between imaging measurements and specimen histology |
|
| Yun et al. (2015) [157] | PsP (16)
TP (17) | 55 | DCE-MRI (ETK model; histogram analysis) |
| = 0.347 (94%, 59%)
= 0.570 (56%, 88%)
No significant difference of between PsP and TP group | Small relative sample size; lack of histological confirmation |
|
