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Contrast Media & Molecular Imaging
Volume 2017 (2017), Article ID 7350429, 8 pages
Research Article

An Individually Optimized Protocol of Contrast Medium Injection in Enhanced CT Scan for Liver Imaging

1Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong 510080, China
2Faculty of Medicine and Dentistry, University of Western Australia, Perth, WA, Australia

Correspondence should be addressed to Xufeng Yang, Zhi Lin, and Zi-Ping Li

Received 28 December 2016; Revised 26 February 2017; Accepted 29 May 2017; Published 10 July 2017

Academic Editor: Silun Wang

Copyright © 2017 Shi-Ting Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the effectiveness of a new individualized contrast medium injection protocol for enhanced liver CT scan. Methods. 324 patients who underwent plain and dual phase enhanced liver CT were randomly assigned to 2 groups: G1 (, individualized contrast medium injection protocol); G2 (, standard contrast medium injection with a dose of 1.5 ml/kg). CT values and ΔHU (CT values difference between plain and enhanced CT) of liver parenchyma and tumor-liver contrast (TLC) during hepatic arterial phase (HAP) and portal venous phase (PVP) and contrast medium dose were measured. The tumor conspicuity of hepatocellular carcinoma (HCC) between two groups was independently evaluated by two radiologists. Results. The mean contrast medium dose of G1 was statistically lower than that of G2. There were no significantly statistical differences in CT values and ΔHU of liver parenchyma during HAP, TLC values during HAP, and PVP between two groups. The CT values and ΔHU of liver parenchyma during PVP of G2 were significantly higher than those of G1. Two independent radiologists were both in substantial conformity in grading tumor conspicuity. Conclusion. Using the individually optimized injection protocol might reduce contrast medium dose without impacting on the imaging quality in enhanced liver CT.