Comparison of ⁶⁸Ga-DOTA-Siglec-9 and ¹⁸F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry

Table 5

Ex vivo biodistribution (% ID/g) of ¹⁸F-FDR-Siglec-9 at 25 min after injection in atherosclerotic and control mice.

Organ	LDLR^−/−ApoB^100/100	C57BL/6N
Aorta			0.0014
Adipose tissue, BAT			0.16
Adipose tissue, WAT			0.67
Blood			0.00025
Brain			0.026
Heart			0.0019
Kidney			0.86
Liver			0.37
Lungs			0.011
Muscle			0.0056
Pancreas			0.011
Plasma			0.00015
Small intestine			<0.0001
Spleen			0.054
Thymus			<0.0001
Urine			0.27

% ID/g = percentage of injected radioactivity dose per gram of tissue; BAT = brown adipose tissue; WAT = white adipose tissue. , 2-tailed Student’s t-test.