Research Article
Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging
Figure 6
Representative in vivo fusion images of c-sestamibi and co(NGR)4 uptake. In “grey” is the uptake of c-sestamibi in myocardium, while uptake of co(NGR)4 imaging is in “hot metal” color. (a) and (c): infarcted heart. Infarct area is signified by decreased uptake of c-sestamibi which is clearly visible in the anterolateral region of the heart (arrowheads). Enhanced uptake of co(NGR)4 is clearly visibly in the infarct area (arrows). (b) and (d): sham-operated heart. Uniform uptake of c-sestamibi can be seen in combination with low overall uptake of co(NGR)4. Note: uptake is color coded and relative to injected dose per animal. SA: short axis; VLA: vertical long axis.
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