Kinetic Modelling of Infection Tracers [¹⁸F]FDG, [⁶⁸Ga]Ga-Citrate, [¹¹C]Methionine, and [¹¹C]Donepezil in a Porcine Osteomyelitis Model

Table 2

Evaluation of the fitting models for the investigated tracers and input functions.

Tracer	Number of OM + ST foci modelled	Plasma input function	Visual impression of fit	Linear Patlak plot	Lowest
^18FFDG	8 + 7	Uncorrected	Good fit of both 2TCM, with rev2TCM giving only minor improvement over irr2TCM. Poor fit of 1TCM.	Yes	rev2TCM
^68GaGa-citrate	2 + 3	Uncorrected	Good fit of both 2TCM, with 1TCM reasonable for some curves.	Yes	irr2TCM or rev2TCM
^11Cmethionine	17 + 7	Uncorrected	Good fits of rev2TCM. Cases with good irr2TCM fit (generally low-lying curves).	No	See main text
		Metab. corr.	For irr2TCM, the fit was improved over the uncorrected input function. Overall, rev2TCM appeared best.	Almost
^11Cdonepezil	11 + 2	Uncorrected	Poor fits for all models.	No	See main text
		Metab. corr.	Good fits with 1TCM, only slightly improved by 2TCM (irr or rev).	Generally not