Contrast Media & Molecular Imaging / 2017 / Article / Tab 2

Research Article

Kinetic Modelling of Infection Tracers [18F]FDG, [68Ga]Ga-Citrate, [11C]Methionine, and [11C]Donepezil in a Porcine Osteomyelitis Model

Table 2

Evaluation of the fitting models for the investigated tracers and input functions.

TracerNumber of OM + ST foci modelledPlasma input functionVisual impression of fitLinear Patlak plotLowest

18FFDG8 + 7UncorrectedGood fit of both 2TCM, with rev2TCM giving only minor improvement over irr2TCM. Poor fit of 1TCM.Yesrev2TCM

68GaGa-citrate2 + 3UncorrectedGood fit of both 2TCM, with 1TCM reasonable for some curves.Yesirr2TCM or rev2TCM

11Cmethionine 17 + 7UncorrectedGood fits of rev2TCM. Cases with good irr2TCM fit (generally low-lying curves).No See main text
Metab. corr.For irr2TCM, the fit was improved over the uncorrected input function. Overall, rev2TCM appeared best.Almost

11Cdonepezil 11 + 2UncorrectedPoor fits for all models.No See main text
Metab. corr.Good fits with 1TCM, only slightly improved by 2TCM (irr or rev).Generally not

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