Research Article
Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models
Figure 3
Colocalization of SSTR2 and autoradiography on CHLA-15 xenografts. CHLA-15 and SK-N-BE(2) tumors were removed immediately after PET/CT imaging. The spatial distribution of the 68Ga-DOTA-TATE uptake was visualized by autoradiography (white signal) in the serial sections of CHLA-15 (a) and SK-N-BE(2) (b) tumors. (c) Representative CHLA-15 tumor section was stained for SSTR2 (red fluorescence) and DAPI (blue fluorescence). (d) The merging image of SSTR2 immunostaining and autoradiograph of the same CHLA-15 tumor section. (e) A representative SK-N-BE(2) tumor section stained for SSTR2 (red fluorescence) and DAPI (blue fluorescence).