Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging

Figure 1

Synthesis of self-assembled multimodal imaging nanoparticles (SAMINs). (a) DTPA dianhydride is reacted with hydrophobically modified HA to produce HA-PBA-DPTA followed by Gd³⁺ complexation to yield paramagnetic HA-PBA-GdDTPA. (b) HA-PBA-Cy7.5 was synthesized as described in the corresponding text. (c) HA-PBA and HA-PBA-DTPA were confirmed with IR spectroscopy by an increase in C=O and O-H stretch peak intensities. (d) SAMIN relaxivity and (e) fluorescence were characterized and indicated the potential for magnetic resonant and optical imaging.

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