Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging

Figure 5

In vitro studies of depth detection and cellular uptake of SAMINs. Fluorescence contrast in three different simulated tissue phantom models demonstrates viability as a contrast agent in a variety of tissue types. (a) shows the contrast fluorescence image of tumor-like inclusions embedded into adipose tissue phantoms, which allows the depth-dependent signal (d) and scattering (g) profiles to be characterized. (b) shows the same data for simulated muscle tissue phantoms, which demonstrate different depth-dependent signal (e) and scattering (h) profiles. The fluorescence imaging data for liver tissue phantoms, for which depth-dependent signal (f) and scattering (i) profiles differ remarkably from both adipose and muscle tissue phantoms.