Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging

Figure 6

Receiver-operating characteristic curve (ROC) analyses for the diagnostic accuracy of MeAIB-PET and MET-PET using semiquantitative analysis. (a) For ROC analysis using SUVmax, the area under the curve (AUC) value for MeAIB PET was 0.83 with standard error 0.090, 95% CI 0.65–1.00, and . The AUC for MET-PET was 0.82 with standard error 0.076, 95% CI 0.67–0.97, and . There was no significance of diagnosis accuracy between them. (b) For ROC analysis using T/N ratio, the AUC value for MeAIB PET was 0.97 with standard error 0.027, 95% CI 0.92–1.02, and . The AUC for MET-PET was 0.69 with standard error 0.10, 95% CI 0.48–0.89, and . These analyses indicated better diagnosis accuracy of MeAIB-PET for brain tumors than MET-PET ().

(a)

(b)