A Hyperfluorinated Hydrophilic Molecule for Aqueous ¹⁹F MRI Contrast Media

Figure 1

Magnetic resonance characteristics of ET1084. (a) Proton decoupled ¹⁹F NMR spectrum from a 300 MHz instrument shows two peaks separated by 0.3 ppm and a single peak from a single pulse frequency sweep in a 9.4T small animal imaging instrument which generates a sharp ¹⁹F MRI image devoid of chemical shift artifacts; (b) dilution studies show that the compound is visible at concentrations of 5 mM from a 10-minute MSME scan at 9.4T, (c) plot of SNR against concentration shows linearity (R² = 0.99); (d) T₁ and T₂ relaxation times estimated by ¹⁹F MRI at 9.4T (details on scan parameters in SI). Data reported as mean ± SD.

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