Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications

Figure 6

In vivo peptide image of human colonic adenoma. (a) SSA (arrow) with flat morphology collected with conventional white light is shown. (b) Fluorescence image following topical administration of peptide KCCFPAQ labeled with FITC shows increased contrast from lesion (arrow). (c) Reflectance and fluorescence images are combined as a (d) ratio to quantify image. (e) Image intensities along horizontal dashed line in (b–d) show a peak located at site of the SSA (arrow). (f) Corresponding histology of SSA shows serrated morphology (arrow) (reprinted with the permission from [81]).

(a)

(b)

(c)

(d)

(e)

(f)