Contrast Media & Molecular Imaging / 2018 / Article / Tab 1

Research Article

Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

Table 1

Biodistribution of 32P-CP particle in nude mice bearing U87MG glioma after intratumor implantation of 32P-CP-PLGA seed ().

Tissue Radioactivity distribution (%ID/g)
0.5 d1 d2 d4 d8 d16 d32 d48 d64 d

TumorMean
1 SD
556.686
24.016
547.778
61.301
626.172
76.528
666.063
59.454
724.118
132.290
903.226
128.155
——————
BloodMean
1 SD
0.007
0.004
0.008
0.008
0.016
0.008
0.020
0.017
0.017
0.013
0.018
0.011
0.010
0.000
0.019
0.005
0.010
0.004
HeartMean
1 SD
0.028
0.012
0.046
0.013
0.079
0.011
0.167
0.015
0.213
0.006
0.128
0.024
0.062
0.015
0.018
0.011
0.027
0.012
LiverMean
1 SD
0.020
0.010
0.035
0.082
0.179
0.115
0.656
0.136
1.125
0.038
0.738
0.100
0.430
0.037
0.369
0.041
0.165
0.016
SpleenMean
1 SD
0.031
0.030
0.069
0.028
0.369
0.121
0.556
0.078
0.913
0.221
0.538
0.061
0.321
0.087
0.469
0.011
0.253
0.112
LungMean
1 SD
0.013
0.000
0.017
0.018
0.206
0.020
0.115
0.027
0.093
0.012
0.068
0.015
0.094
0.013
0.071
0.021
0.062
0.010
KidneyMean
1 SD
0.033
0.030
0.057
0.028
0.137
0.021
0.074
0.027
0.109
0.017
0.065
0.013
0.039
0.007
0.039
0.034
0.021
0.010
StomachMean
1 SD
0.009
0.004
0.017
0.003
0.404
0.011
0.030
0.008
0.039
0.017
0.038
0.011
0.026
0.015
0.049
0.021
0.036
0.019
IntestineMean
1 SD
0.023
0.010
0.099
0.038
0.154
0.035
0.159
0.063
0.292
0.127
0.225
0.051
0.113
0.031
0.176
0.063
0.148
0.030
PancreasMean
1 SD
0.008
0.000
0.024
0.002
0.125
0.011
0.312
0.015
0.057
0.024
0.051
0.01
0.043
0.021
0.035
0.012
0.055
0.022
BrainMean
1 SD
0.017
0.009
0.006
0.011
0.028
0.01
0.099
0.023
0.065
0.024
0.033
0.011
0.037
0.012
0.041
0.021
0.024
0.014
ThyroidMean
1 SD
0.016
0.000
0.034
0.007
0.026
0.011
0.044
0.013
0.032
0.015
0.042
0.021
0.032
0.011
0.041
0.022
0.035
0.013
TestisMean
1 SD
0.022
0.010
0.021
0.013
0.038
0.022
0.021
0.008
0.042
0.010
0.058
0.031
0.029
0.008
0.033
0.016
0.036
0.011
BoneMean
1 SD
0. 233
0.021
0.377
0.035
0.369
0.121
1.049
0.236
1.518
0.049
1.081
0.211
0.930
0.084
0.569
0.308
0.656
0.182
MuscleMean
1 SD
0.011
0.000
0.035
0.010
0.034
0.015
0.043
0.017
0.052
0.023
0.041
0.026
0.034
0.017
0.029
0.021
0.025
0.020

ID: injected dose. 0.5, 1, 2, 4, 8, 16, 32, 48, and 64 d were time at which animals were anesthetized and sacrificed, blood was collected, tissues were weighed, and radioactivity was quantified. mice at each time point.