Contrast Media & Molecular Imaging / 2018 / Article / Tab 2

Research Article

Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

Table 2

Biodistribution of 32P-CP particle in nude mice bearing U87MG glioma after intratumor injection of 32P-CP colloids ().

Tissue Radioactivity distribution (%ID/g)
0.5 d1 d2 d4 d8 d16 d32 d48 d64 d

TumorMean
1 SD
429.1
110.2
455.60
265.72
570.5
159.4
470.76
218.05
525.57
52.21
676.25
61.15
——————
BloodMean
1 SD
0.057
0.021
0.073
0.035
0.079
0.010
0.046
0.011
0.022
0.047
0.048
0.014
0.02
0.011
0.079
0.014
0.070
0.012
HeartMean
1 SD
0.171
0.052
0.124
0.013
0.232
0.151
0.207
0.105
0.148
0.049
0.097
0.054
0.009
0.035
0.246
0.113
0.183
0.071
LiverMean
1 SD
0.253
0.110
0.146
1.077
1.690
0.745
1.656
1.076
2.918
0.076
1.219
0.171
1.122
2.037
2.629
0.041
2.465
0.016
SpleenMean
1 SD
0.324
0.197
0.249
0.128
0.559
0.121
1.241
0.052
0.913
0.021
0.769
0.061
0.334
0.087
0.469
0.011
0.356
0.019
LungMean
1 SD
0.233
0.103
0.163
0.018
0.239
0.078
0.256
0.127
0.433
0.212
0.512
0.015
0.222
0.013
0.041
0.021
0.052
0.010
KidneyMean
1 SD
0.192
0.074
0.153
0.028
0.269
0.121
0.256
0.127
0.019
0.017
0.071
0.092
0.210
0.007
0.269
0.034
0.056
0.019
StomachMean
1 SD
0.056
0.034
0.097
0.003
0.016
0.011
0.033
0.008
0.019
0.017
0.113
0.011
0.241
0.015
0.049
0.021
0.036
0.019
IntestineMean
1 SD
0.203
0.109
0.038
0.012
0.154
0.035
0.159
0.063
0.156
0.127
0.136
0.051
0.408
0.031
0.176
0.063
0.248
0.030
PancreasMean
1 SD
0.030
0.024
0.101
0.002
0.049
0.011
0.074
0.015
0.077
0.024
0.182
0.01
0.020
0.021
0.035
0.012
0.055
0.022
BrainMean
1 SD
0.017
0.019
0.026
0.021
0.011
0.010
0.036
0.023
0.024
0.014
0.013
0.011
0.008
0.012
0.013
0.021
0.024
0.014
ThyroidMean
1 SD
0.016
0.021
0.077
0.007
0.026
0.011
0.044
0.013
0.026
0.015
0.022
0.021
0.012
0.011
0.021
0.022
0.035
0.013
TestisMean
1 SD
0.022
0.012
0.041
0.013
0.038
0.022
0.021
0.008
0.042
0.010
0.018
0.031
0.029
0.008
0.033
0.016
0.036
0.011
BoneMean
1 SD
0.762
0.421
2.343
0.035
2.369
0.121
3.856
0.236
4.004
1.093
3.541
0.211
2.605
0.084
2.869
0.308
2.656
0.182
MuscleMean
1 SD
0.007
0.003
0.083
0.010
0.034
0.015
0.043
0.017
0.046
0.023
0.092
0.026
0.053
0.017
0.049
0.021
0.045
0.020

ID: injected dose. 0.5, 1, 2, 4, 8, 16, 32, 48, and 64 d were time at which animals were anesthetized and sacrificed, blood was collected, tissues were weighed, and radioactivity was quantified. mice at each time point.