Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging

Table 1

Summary of ¹³C metabolite quantification. Metabolite values are mean ± SD.

	Lactate/pyruvate^a,b	Lactate/total carbon^a,b	Normalized lactate^a,b	Normalized pyruvate
T2-hyperintense lesion ()	0.70 ± 0.24	0.36 ± 0.08	2.9 ± 1.1	1.0 ± 0.29
Contralateral brain ()	0.28 ± 0.11	0.18 ± 0.07	1.1 ± 0.33	1.1 ± 0.35
Healthy rat brain ()	0.20 ± 0.06	0.14 ± 0.03	1.2 ± 0.25	1.1 ± 0.25

^aSignificant difference between T₂-hyperintense lesion and contralateral brain (). ^bSignificant difference between T₂-hyperintense lesion and healthy rat brain ().