In Vivo 6-([¹⁸F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity

Figure 1

Comparison of values of [¹⁸F]FAHA in the brain calculated from multicompartmental pharmacokinetic model and graphical analyses before and after drug administration. (a) The multicompartmental pharmacokinetic model and (b) Patlak plot both indicated that was significantly increased after cisplatin administration in Groups A (Cis 2 mg/kg) and B (Cis 4 mg/kg), but there was no difference in Group C (Cis 4 mg/kg + SAHA 300 mg/kg). (c) In Groups A and B, the radioactivity of accumulated [¹⁸F]FDG was significantly decreased after cisplatin administration; however, no differences were observed in Group C. ; .

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