Review Article
Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA
Figure 8
Hepatocyte transport activity and liver perfusion. Gd-BOPTA hepatocyte concentrations (d) over time according to clearances from sinusoids to liver (SINCLLIVER, a), clearances from hepatocytes to bile canaliculi (HCCLBC, b), and clearances from hepatocytes back to interstitium (HCCLINT, c). Livers are perfused with 200 µM Gd-BOPTA (45 to 75 min) and Krebs–Henseleit bicarbonate (KHB) solution (75 to 105 min) at various flow rates: 24 ml/min (black circles), 30 ml/min (white circles), or 36 ml/min (grey circles). Adapted from [32] with permission.
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