In Vivo and In Vitro Characteristics of Radiolabeled Vesamicol Analogs as the Vesicular Acetylcholine Transporter Imaging Agents

Table 3

The ratio of binding affinity (Ki) of enantiomers of vesamicol analogs for VAChT, σ₁, and σ₂ receptors ((−)-body/(+)-body).

	The ratio of binding affinity (Ki) of enantiomers of vesamicol analogs for VAChT, σ1, and σ2 receptors ((−)-body/(+)-body)			Tissue preparations for VAChT
	VAChT	σ1	σ2
Vesamicol [55]	0.034	4.88	1.12	Rat brain membranes
FEOBV (2) [45]	0.344	0.78	—	rVAChT-PC12 cell
MIBT (8) [55]	39.6	0.23	1.45	Rat brain membranes
FBT (9) [60]	72.7	1.03	3.05	Torpedo californica
oIV (10) [62]	0.063	4.29	2.80	Rat brain membranes
OMV (11) [63]	0.30	3.15	1.22	Rat brain membranes
OIDV (13) [66]	0.28	0.53	0.59	Rat brain membranes
FBBV (18) [71]	0.038	3.54	1.15	Torpedo californica
19 [80]	0.047	0.47	1.74	rVAChT-PC12 cell
TZ659 (20) [81]	0.041	0.85	1.47	rVAChT-PC12 cell
VAT (21) [71]	0.045	1.0	>1.28	rVAChT-PC12 cell
22 [84]	0.13	1.50	0.55	rVAChT-PC12 cell