Research Article
Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice
Figure 6
Application of the MP pCASL sequence in mice with intracerebral 4T1-GFP metastatic tumours showing a gadolinium enhancing rim and a nonenhancing core region. (a) T1-weighted image showing core (nongadolinium-enhancing central regions; dotted outline) and rim (gadolinium-enhancing regions; solid outline) of metastatic foci. (b) CBF maps with the same ROIs indicated. (c) Graph showing CBF values in core, rim, and contralateral regions; a significant decrease () in perfusion is evident between the core and rim regions of tumours (d-e). Histological comparison of microvessel area fraction in core (d) and rim (e) regions. Scale bars = 20 µm. (f) Graph showing quantitation of microvessel area fraction in core, rim, and contralateral striatum regions; a significant increase in vessel area fraction is evident in core regions compared with both the rim regions () and normal tissue in the contralateral striatum. ; .
| (a) |
| (b) |
| (c) |
| (d) |
| (e) |
| (f) |