Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents
Table 1
Biodistribution of 131I-H33258 in necrotic-muscle bearing mice models.
Organ
Uptake (% ID/g)
3 h
6 h
12 h
24 h
Blood
0.77 ± 0.13
0.46 ± 0.01
0.13 ± 0.04
0.06 ± 0.02
Brain
0.03 ± 0.01
0.02 ± 0.02
0.01 ± 0.00
0.01 ± 0.00
Thyroid
0.57 ± 0.11
0.34 ± 0.08
0.23 ± 0.03
0.05 ± 0.01
Lung
0.48 ± 0.10
0.39 ± 0.09
0.32 ± 0.01
0.11 ± 0.02
Heart
0.18 ± 0.06
0.12 ± 0.01
0.06 ± 0.01
0.04 ± 0.01
Liver
1.49 ± 0.15
1.02 ± 0.30
0.57 ± 0.10
0.24 ± 0.04
Spleen
1.14 ± 0.15
0.67 ± 0.11
0.34 ± 0.37
0.14 ± 0.03
Stomach
1.62 ± 0.12
0.81 ± 0.17
0.44 ± 0.01
0.17 ± 0.08
Pancreas
0.30 ± 0.06
0.32 ± 0.06
0.07 ± 0.00
0.05 ± 0.01
S intestine
0.61 ± 0.14
0.40 ± 0.11
0.06 ± 0.01
0.04 ± 0.02
L intestine
0.47 ± 0.10
0.24 ± 0.20
0.06 ± 0.02
0.04 ± 0.02
Kidney
1.11 ± 0.16
0.84 ± 0.13
0.56 ± 0.05
0.17 ± 0.05
Bladder
2.13 ± 0.28
1.60 ± 0.44
0.09 ± 0.02
0.05 ± 0.04
V muscle
0.16 ± 0.03
0.10 ±0.03
0.03 ± 0.01
0.02 ± 0.01
N muscle
0.93 ± 0.12
0.61 ± 0.08
0.35 ± 0.03
0.24 ± 0.04
N/V ratio
5.81 ± 0.55
6.19 ± 0.92
10.70 ± 1.72
9.75 ± 1.10
Data are presented as mean ± SD for four mice. S intestine: small intestine; L intestine: large intestine; V muscle: viable muscle; N muscle: necrotic muscle; N/V ratio: necrotic/viable muscle ratio. , compared with the uptake values of 131I-H33258 in viable muscle at each time point.
