Molecular Imaging of Aminopeptidase N in Cancer and Angiogenesis

Figure 1

Structure of the APN enzyme. (a) The monomeric sequence is composed of 967 residues and 7 sections as designated by color. From left to right, the order is as follows: cytoplasmic domain, transmembrane section, Ser/Thr rich stalk, and ectodomain I, II, III, and IV. (b) The ribbon structure of how the dimeric APN enzyme is likely oriented on the plasma membrane. The yellow spheres are the active sites for the zinc ions, and the N-linked oligosaccharides are represented by sticks. Reprinted (adapted) with permission from Wong et al. [31], copyright (2012) from American Society for Biochemistry and Molecular Biology.