Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Figure 4

PET images over time of [¹¹C]MT107 (SUV, maximal intensity projections). (a) Control scan, 7.1 MBq [¹¹C]MT107. (b) Scan after cyclosporine treatment (50 mg/kg, i.v.), 11.7 MBq [¹¹C]MT107. The time windows are indicated. SCID mice.

(a)

(b)