Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice

Figure 7

[¹¹C]MT107 experimental and modelled of blood plasma, liver, gallbladder, intestines, kidneys, peripheral tissue, and urine (modelled only). (a–d) [¹¹C]MT107 under control conditions. Vehicle (13% ethanol, 2 ml/kg) was administered 30 min before tracer to the animal in (d) as a control. (e–h) [¹¹C]MT107 after cyclosporine treatment. Circles, experimental data derived from the PET images. Squares (h), available experimental data from dissection at the end of the scan (68 min). Lines, modelled . Colours and line style, see Figure 6. and BW are indicated in the panels. The respective curves are shown in Supplementary Figure . SCID mice.

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