Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice
Table 1
Plasma pharmacokinetics and PBPK modelling results based on [11C]AM7 and [11C]MT107 PET data.
PBPK parameters were calculated from the fitted k according to (2) and (3) and the model in Figure 2. values for [11C]AM7 and mean with standard deviations for [11C]MT107; n, number of scans; decrease compared to [11C]MT107 control; [11C]AM7, includes × (% contribution shown in brackets; see Figure 2) , not determined; ratios > 2.0; ratios < 1.1. ;.