Multimodal PET/MRI Imaging Results Enable Monitoring the Side Effects of Radiation Therapy

Figure 4

The effect of irradiation on the brain ADC values. The mean ADC values of the left (irradiated) brain regions (Vent: ventricles; Th: thalamus; Ctx: cortex; Hth: hypothalamus; Hc: hippocampus; Cb: cerebellum; Amy: amygdala) are shown at five different time points by 5 Gy (a) and 20 Gy (b) dose groups. The boxplots show median with quartiles, minimum, and maximum. The correlation maps of the ADC values of the left versus right brain areas (regardless of the time points) by 5 Gy (c) and 20 Gy (d) dose groups are shown. The heat maps visualize the Pearson correlation of irradiation effects between each investigated brain region. The time trend analysis of the whole brain ADC changes is shown in (e).

(a)

(b)

(c)

(d)

(e)