Table 1: Radiosynthesis characteristics of the different 18F labeled bile acids. The overall synthesis time was 100 minutes. n.d.c. RY: nondecay corrected radiochemical yield. RP: radiochemical purity. Data are mean ± SD.

n.d.c. RY (%)
(n = 3)
18F labeling of precursor (%)
(n = 3)
RP (%)LogD
(n = 3)

3α-[18F]FCA10.56 ± 2.0230.31 ± 1.28>990.92 ± 0.17
3β-[18F]FGCA4.28 ± 0.3911.51 ± 2.55>990.011 ± 0.037
3β-[18F]FCDCA9.57 ± 1.5128.27 ± 5.02>991.42 ± 0.16
12β-[18F]FCA<0.52.82 ± 1.14NANA
7β-[18F]FCA<0.51.23 ± 0.26NANA