Table 3: Metrics of the 18F labeled bile acids time-activity curves. The values are expressed as mean ± SD (n = 3). Significant differences compared to the 3β-[18F]FCA values are marked with . A value ≤ 0.05 was considered significant. GBI = gallbladder and intestines; AB = arterial blood.

3β-[18F]FCA3α-[18F]FCA3β-[18F]FGCA3β-[18F]FCDCA

AUC liver (% ID⋅min)1785 ± 1941065 ± 1711907 ± 582449 ± 111
Max% ID liver (%)63.80 ± 2.6158.58 ± 3.1963.58 ± 1.8451.01 ± 3.94
Time-to-peak liver (min)5.33 ± 0.243.33 ± 0.625.17 ± 0.6210.17 ± 0.62
AUC GBI (% ID⋅min)3499 ± 3404184 ± 1093021 ± 2762515 ± 189
Max% ID GBI (%)83.44 ± 9.2788.70 ± 2.3875.32 ± 6.3060.93 ± 7.29
AUC AB concentration (MBq⋅min/mL)13003 ± 103214007 ± 215010192 ± 140428437 ± 4380
Biliary clearance (mL/min)0.46 ± 0.080.49 ± 0.100.47 ± 0.070.18 ± 0.04