Contrast Media & Molecular Imaging / 2018 / Article / Fig 1

Research Article

111In-DANBIRT In Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis

Figure 1

In vivo biodistribution of 111In-DANBIRT. apoE−/− mice after 8 weeks of dietary assessment were injected with 26 Mbq (∼700 μCi) of 111In-DANBIRT. After 3 hours after injection, mice were euthanized and tissues were harvested for radioactive uptake analysis. Muscle (a) demonstrated low uptake, as expected (determined as the background tissue for other tissues uptake normalization). High uptake in the liver (b) was observed, due to high blood distribution and an abundance of immune cells. Results showed higher uptake in the aorta, serum, and leukocytes (c–e) in mice that were fed a HFD (). Two-tailed Student’s t-test was used for statistical analysis () (n of 4 per group).

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