¹¹¹In-DANBIRT In Vivo Molecular Imaging of Inflammatory Cells in Atherosclerosis

Figure 5

24-hour ¹¹¹In-DANBIRT 3D autoradiography. (a) shows a representative image of the right and left common carotid arteries as they were clearly identified and isolated using determined ROI using fused autoradiography images to identify the left common carotid (LCC) and right common carotid (RCC) that were isolated and identified in red dots (white arrows point to the labeled ROI in each figure). (b-c) show representative images of ¹¹¹In-DANBIRT uptake in HFD-fed mice in the aortic arch (AA) and aortic vessel outflow (AV) (black arrows point to the labeled ROI in each figure). (d) shows a representative image of ¹¹¹In-DANBIRT uptake in normal-diet-fed mice in the aortic arch (AA) (black arrows point to the labeled ROI in each figure). Thymus (Tm) and thyroid (Tr) are shown as landmarks for anatomical references (black arrows point to the labeled ROI in each figure). (e) shows statistical analysis of the uptake of ¹¹¹In-DANBIRT in the aortic arch and no difference between groups with increased ¹¹¹In-DANBIRT uptake in HFD-fed mice even after 24 hours after injection in the carotid arteries (with no statistical significance) and the thymus (). One-way ANOVA with multiple comparisons was used for statistical analysis () (n of 4 per group).

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