Radiation Necrosis, Pseudoprogression, Pseudoresponse, and Tumor Recurrence: Imaging Challenges for the Evaluation of Treated Gliomas

Table 1

Cutoff values of PET tracers for the detection of glioma recurrence.

Study	Modality	Tracer	Parameter	Cutoff	Sensitivity (%)	Specificity (%)
Deuschl et al. [32]	PET/MRI	^11C-methionine	Max T/N	1.8	97.14	93.33
			Mean T/N	1.3
Tripathi et al. [33]	PET/CT	^11C-methionine	Max T/N	1.9	95	89
Terakawa et al. [34]	PET	^11C-methionine	Mean T/N	1.58	75	75
Herholz et al. [44]	PET	^11C-methionine	T/N	1.47	76	87
Garcia et al. [45]	PET	^11C-methionine	T/N	2.35	90.5	100
Takenaka et al. [46]	PET	^11C-methionine	T/N	2.51	91.2	81.4
Galldinks et al. [36]	PET	^18F-FET	Max T/N	2.3	100	91
Kebir et al. [37]	PET	^18F-FET	Max T/N	1.9	84	86
Jena et al. [43]	PET/MRI	^18F-FDG	Max T/N	1.579	93.3	72.7
			Mean T/N	1.179	90	81.8
Enslow et al. [47]	PET	^18F-FDG	T/N	1.83	100	75
			Max T/N	6.2	90.9	75