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Contrast Media & Molecular Imaging
Volume 2018 (2018), Article ID 6830105, 10 pages
Research Article

Brain Network Alterations in Alzheimer’s Disease Identified by Early-Phase PIB-PET

1Department of Nuclear Medicine, General Hospital of the Chinese People’s Liberation Army, 28 Fuxing Rd, Beijing, China
2National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, 95 Zhongguancun East Road, Beijing, China
3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Correspondence should be addressed to Yong Fan and Jiahe Tian

Received 23 August 2017; Revised 1 December 2017; Accepted 12 December 2017; Published 8 January 2018

Academic Editor: Giorgio Biasiotto

Copyright © 2018 Liping Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to identify the brain networks from early-phase 11C-PIB (perfusion PIB, pPIB) data and to compare the brain networks of patients with differentiating Alzheimer’s disease (AD) with cognitively normal subjects (CN) and of mild cognitively impaired patients (MCI) with CN. Forty participants (14 CN, 12 MCI, and 14 AD) underwent 11C-PIB and 18F-FDG PET/CT scans. Parallel independent component analysis (pICA) was used to identify correlated brain networks from the 11C-pPIB and 18F-FDG data, and a two-sample t-test was used to evaluate group differences in the corrected brain networks between AD and CN, and between MCI and CN. Our study identified a brain network of perfusion (early-phase 11C-PIB) that highly correlated with a glucose metabolism (18F-FDG) brain network and colocalized with the default mode network (DMN) in an AD-specific neurodegenerative cohort. Particularly, decreased 18F-FDG uptake correlated with a decreased regional cerebral blood flow in the frontal, parietal, and temporal regions of the DMN. The group comparisons revealed similar spatial patterns of the brain networks derived from the 11C-pPIB and 18F-FDG data. Our findings indicate that 11C-pPIB derived from the early-phase 11C-PIB could provide complementary information for 18F-FDG examination in AD.