Brain Network Alterations in Alzheimer’s Disease Identified by Early-Phase PIB-PET

Table 1

Demographic, clinical, and neuropsychological characteristics of the patients.

	AD	MCI	CN	value
Sex (male/female)	4/10	8/4	5/9	0.13
Age (years)				0.02
Education (years)				0.52
Amyloid status (PIB +/−)	12/2	9/3	1/13	<0.001
MMSE				<0.001
CDR		0.5	0	<0.001

With the cerebellar cortex as the reference region, voxel wise semiquantitative calculations of global standardized uptake value ratios (SUVR) for all subjects were performed. The amyloid status was reflected by the Pittsburgh Compound B (PIB) burden and the cutoff value of SUVR was set to 1.15 to determine PIB positive or negative. Chi-square was used for the gender comparison; one-way ANOVA with a Bonferroni post hoc test was used for age and neuropsychological test comparisons. < 0.05. AD: Alzheimer’s disease; MCI: mild cognitively impaired; CN: cognitively normal; MMSE: Mini-Mental State Examination; CDR: Clinical Dementia Rating.