Brain Network Alterations in Alzheimer’s Disease Identified by Early-Phase PIB-PET

Table 3

¹⁸F-FDG–revealed hypometabolic brain areas differentiating AD and CN groups.

Brain region	Voxel-level
	T	Z
Limbic lobe/R ParaHippo	6.75	5.05	0.000	22	−4	−38
	4.78	3.99	0.000	22	6	−24
R STG/BA39	6.40	4.88	0.000	58	−58	26
	5.18	4.23	0.000	54	−54	44
R MTG/ ITG	5.99	4.68	0.000	54	−64	18
	5.85	4.60	0.000	66	−40	−14
Rectal gyrus	5.89	4.62	0.000	8	32	−26
Limbic lobe/L ParaHippo	5.79	4.57	0.000	−22	4	−22
PCC/BA29	5.64	4.49	0.000	−2	−42	20
	5.51	4.41	0.000	0	−26	32
R MFG/ACC	5.09	4.18	0.000	2	50	−12
	4.88	4.05	0.000	4	38	24
R SPL/BA7	5.01	4.13	0.000	36	−58	54
	4.70	3.94	0.000	40	−48	50
L STG/BA13	4.95	4.10	0.000	−50	−4	0
	4.42	3.76	0.000	−46	6	−2
L STG/BA42/Insula	4.79	4.00	0.000	−64	−36	18
	3.82	3.36	0.000	−54	−32	18
L STG/BA38	4.73	3.96	0.000	26	6	−48
L IFG/BA47	4.70	3.94	0.000	−40	24	−16
	4.09	3.55	0.000	−38	14	−12

Threshold: = 3.45, = 0.001; Extent threshold: = 50 voxel, voxel size:  mm. ¹⁸F-FDG: fludeoxyglucose F 18; AD: Alzheimer’s disease; CN: cognitively normal; STG: superior temporal gyrus; BA: Brodmann area; MTG: middle temporal gyrus; ITG: inferior temporal cortex; PCC: posterior cingulate cortex; MFG: medial frontal gyrus; ACC: anterior cingulate cortex; SPL: superior parietal lobe; IFG: inferior frontal gyrus.