Research Article
Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/64Cu PET Imaging
Figure 2
Physicochemical characterization during the functionalization of GdNP. (a) DLS diagrams of SiGdNP (black), SiGdNP @ D-1 (DOTAGA) (blue), and SiGdNP @ N-1 (NODAGA) (red). (b) HPLC chromatograms of SiGdNP (before functionalization) (black) and SiGdNP @ D-1 (after functionalization with DOTAGA at 80°C) (red). (c) HPLC chromatograms of SiGdNP (before functionalization) (black) and SiGdNP @ N-1 (after functionalization with NODAGA at 80°C) (red). The concentration of samples analyzed by HPLC was at 5 mM in Gd. Eu titration curves λex = 395 nm, λem = 594 nm of SiGdNP (d), SiGdNP @ D-1 (e), and SiGdNP @ N-1 (f).
(a) |
(b) |
(c) |
(d) |
(e) |
(f) |