Preparation of ⁶⁸Ga-PSMA-11 with a Synthesis Module for Micro PET-CT Imaging of PSMA Expression during Prostate Cancer Progression

Figure 2

(a) Distribution of  ⁶⁸Ga-PSMA-11 in nude mice bearing PC-3, CWR22Rv1, and LNCaP xenografts 1 h after the intravenous injection. The mice bearing LNCaP xenografts with preinjection of 2.5 μg (low dose) or 250 g (high dose) of 2-PMPA were used as blocking groups (10 min before radiotracer administration). (b) The graph of tumor/kidney and tumor/liver uptake ratio in mice bearing different type of PCa xenografts with or without 2-PMPA. (c) Representative images (original magnification 100x) of CWR22Rv1 and LNCaP cells with anti-PSMA antibody (AlexaFluo488, red) stained and nucleus stained (Hoechst, blue).

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