Preparation of 68Ga-PSMA-11 with a Synthesis Module for Micro PET-CT Imaging of PSMA Expression during Prostate Cancer Progression
LNCaP tumor uptake (% ID and % ID/cm3) of 68Ga-PSMA-11 with tumor growth and relationship with PSMA expression. (a) Graph displays the LNCaP tumor uptake (% ID and % ID/cm3) changes with tumor anatomical volume increase. Tumor uptake (% ID/cm3) reached peak when anatomical volume was about 0.5 cm3, less than that of % ID tumor uptake (1.2 cm3). (b) Tumor uptake (% ID/cm3) of radiotracer in tumors with different PSMA expression and anatomical volume. When tumor size was less than 0.5 cm3, tumor uptake (% ID/cm3) of 68Ga-PSMA-11 was LNCaP > CWR22Rv1 > PC-3 and it decreased when tumor grew more than 1.0 cm3. (c) LNCaP tumor uptake (% ID/cm3) of radiotracer with functional tumor volume changes. LNCaP tumor uptake (% ID/cm3) was more than 6.0. In four mice bearing large LNCaP tumor xenografts with anatomical volume > 1.0 cm3 and functional volume of about 0.4 cm3, the tumor uptake (% ID/cm3) is less than 6.0 (below horizontal line). (d) Tumor uptake of 68Ga-PSMA-11 (% ID/cm3) based on functional volume correlated well with PSMA expression determined by flow cytometry in a linear manner (,, and ).
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