Iso-Osmolar Iodixanol Induces Less Increase in Circulating Endothelial Microparticles In Vivo and Less Endothelial Apoptosis In Vitro Compared with Low-Osmolar Iohexol

Figure 3

The effects of contrast media on apoptosis-related proteins in HUVECs. HUVECs were treated with 20 vol% of iodixanol or iohexol for 4 h and expression of Bcl-2 (a), Bax (b), caspase 3, and cleaved caspase-3 (c) was measured by Western blotting. These experiments were repeated at least 3 times. Data represents mean ± SD. Complete growth medium served as control. , , and versus control; , and versus iodixanol.

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