MT1-MMP as a PET Imaging Biomarker for Pancreas Cancer Management

Figure 2

CAPAN-2-tumour-bearing mice injected with ⁶⁸Ga-DOTA-AF7p probes. (a) PET/CT image of representative mouse with subcutaneous CAPAN-2 xenograft (white arrows) that was injected with ⁶⁸Ga-DOTA-AF7p-1. Image was acquired 90 min after injection. (b) Immunohistochemistry of tumour tissue from xenografted mice. MT1-MMP was detected using LEM2/15 antibody. Scale bar: 1000 µm. Higher magnification of the boxed area is shown at the right corner. Scale bar: 50 µm. (c) Tumour uptake (expressed as %ID/g) of ⁶⁸Ga-DOTA-AF7p-1 and ⁶⁸Ga-DOTA-AF7p-2 probes as quantified by PET imaging. (d) Tumour-to-blood ratio derived from PET images for both radiolabelled probes.

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