Table of Contents Author Guidelines Submit a Manuscript
Contrast Media & Molecular Imaging
Volume 2018, Article ID 9165458, 7 pages
https://doi.org/10.1155/2018/9165458
Research Article

Amyloid-Beta Radiotracer [18F]BF-227 Does Not Bind to Cytoplasmic Glial Inclusions of Postmortem Multiple System Atrophy Brain Tissue

1Lyon Neuroscience Research Center, CNRS UMR5292, INSERM U1028, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France
2Hospices Civils de Lyon, Groupement Hospitalier Est, Lyon, France
3Institute of Chemistry and Biochemistry, CNRS UMR5246, Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne, France
4CERMEP-Imaging Platform, Bron, France

Correspondence should be addressed to Fabien Chauveau; rf.pemrec@uaevuahc

Received 24 August 2017; Revised 22 December 2017; Accepted 1 January 2018; Published 6 February 2018

Academic Editor: Ralf Schirrmacher

Copyright © 2018 Mathieu Verdurand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Foundation Opens -Million Competition for Alpha-Synuclein PET Tracer. J Nucl Med 2016;57:10N–10N.
  2. D. P. Bagchi, L. Yu, J. S. Perlmutter et al., “Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent,” PLoS ONE, vol. 8, no. 2, Article ID e55031, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. W. Chu, D. Zhou, V. Gaba et al., “Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils,” Journal of Medicinal Chemistry, vol. 58, no. 15, pp. 6002–6017, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. K. L. Neal, N. B. Shakerdge, S. S. Hou et al., “Development and screening of contrast agents for in vivo imaging of Parkinson's disease,” Molecular Imaging and Biology, vol. 15, no. 5, pp. 585–595, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Zhang, H. Jin, P. Padakanti et al., “Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein,” Applied Sciences, vol. 4, no. 1, pp. 66–78, 2014. View at Publisher · View at Google Scholar
  6. A. Kikuchi, A. Takeda, N. Okamura et al., “In vivo visualization of α-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy,” Brain, vol. 133, no. 6, pp. 1772–1778, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. T. Fodero-Tavoletti, R. S. Mulligan, N. Okamura et al., “In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies,” European Journal of Pharmacology, vol. 617, no. 1-3, pp. 54–58, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. MRC London Neurodegenerative Diseases Brain Bank; MRC UK Brain Banks Network; No. Access: 1, Last: 2015. [BIORESOURCE].
  9. P. Paul-Gilloteaux, X. Heiligenstein, M. Belle et al., “EC-CLEM: Flexible multidimensional registration software for correlative microscopies,” Nature Methods, vol. 14, no. 2, pp. 102-103, 2017. View at Publisher · View at Google Scholar · View at Scopus
  10. F. De Chaumont, S. Dallongeville, N. Chenouard et al., “Icy: an open bioimage informatics platform for extended reproducible research,” Nature Methods, vol. 9, no. 7, pp. 690–696, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G. G. Kovacs, U. Wagner, B. Dumont et al., “An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology,” Acta Neuropathologica, vol. 124, no. 1, pp. 37–50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Ahmed, Y. T. Asi, A. Sailer et al., “The neuropathology, pathophysiology and genetics of multiple system atrophy,” Neuropathology and Applied Neurobiology, vol. 38, no. 1, pp. 4–24, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Harada, N. Okamura, S. Furumoto et al., “Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 40, no. 1, pp. 125–132, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. V. J. Lowe, G. Curran, P. Fang et al., “An autoradiographic evaluation of AV-1451 Tau PET in dementia,” Acta Neuropathologica Communications, vol. 4, no. 1, article no. 58, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Levigoureux, S. Lancelot, C. Bouillot et al., “Binding of the PET radiotracer [18F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice,” Current Alzheimer Research, vol. 11, no. 10, pp. 955–960, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Koga, M. Ono, N. Sahara, M. Higuchi, and D. W. Dickson, “Fluorescence and autoradiographic evaluation of tau PET ligand PBB3 to α-synuclein pathology,” Movement Disorders, vol. 32, no. 6, pp. 884–892, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Gerhard, R. B. Banati, G. B. Goerres et al., “[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy,” Neurology, vol. 61, no. 5, pp. 686–689, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Ye, J. L. Morgenstern, A. D. Gee, G. Hong, J. Brown, and A. Lockhart, “Delineation of positron emission tomography imaging agent binding sites on β-amyloid peptide fibrils,” The Journal of Biological Chemistry, vol. 280, no. 25, pp. 23599–23604, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Ono, N. Sahara, K. Kumata et al., “Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies,” Brain : a journal of neurology, vol. 140, no. 3, pp. 764–780, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. IG. McKeith, DW. Dickson, J. Lowe et al., “Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium,” Neurology, vol. 2005, no. 65, pp. 1863–1872.