Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with ¹⁸F-GE-180, a Radiotracer for Translocator Protein (TSPO)

Table 2

¹⁸F-GE-180 in vivo PET/CT imaging results at 20–30 minutes after injection.

	LDLR^–/–ApoB^100/100 ()	C57BL/6N ()	value	LDLR^–/–ApoB^100/100, block ()	value
Adrenal gland	3.95 ± 0.71	4.58 ± 0.58		2.21 ± 0.44	0.003
Aorta	0.87 ± 0.18	1.02 ± 0.12		0.90 ± 0.13
BAT	0.37 ± 0.12	0.37 ± 0.12		1.37 ± 0.29	<0.001
Blood	0.48 ± 0.10	0.56 ± 0.10		0.81 ± 0.16	0.003
Bone	0.56 ± 0.15	0.45 ± 0.11		0.51 ± 0.24
Brain	0.57 ± 0.10	0.71 ± 0.08	0.028	0.32 ± 0.02	0.002
Intestine and its contents	3.36 ± 0.88	2.96 ± 0.22		23.21 ± 10.85	<0.001
Kidney	6.23 ± 0.85	5.01 ± 0.84	0.038	2.40 ± 0.47	<0.001
Liver	2.19 ± 0.68	2.53 ± 0.32		2.52 ± 0.44
Lung	2.95 ± 0.54	3.30 ± 0.72		0.91 ± 0.37	0.001
Muscle	0.27 ± 0.13	0.34 ± 0.07		0.41 ± 0.06
Myocardium	2.58 ± 0.51	3.10 ± 0.46		0.75 ± 0.09	<0.001
Pancreas	1.86 ± 0.48	1.87 ± 0.24		1.90 ± 0.45
Spleen	3.65 ± 0.65	3.69 ± 0.86		1.44 ± 0.35	0.002
Thymus	1.02 ± 0.28	1.29 ± 0.14		1.02 ± 0.08
Urine	0.15 ± 0.03	0.19 ± 0.17		1.18 ± 0.47	<0.001
WAT	0.12 ± 0.02	0.15 ± 0.05		0.48 ± 0.41	0.022

The results are expressed as mean standardized uptake values ± standard deviation extracted from the PET/CT images. values are derived from ANOVA with Dunnett’s correction, LDLR^–/–ApoB^100/100 mice as the control group. Blank cell in column indicates insignificant value (>0.05). Block: excess amount of nonradioactive GE-180 given intravenously 5 minutes before administration of ¹⁸F-GE-180.