Positron Emission Tomography Imaging of Macrophages in Atherosclerosis with ¹⁸F-GE-180, a Radiotracer for Translocator Protein (TSPO)

Table 3

¹⁸F-GE-180 ex vivo biodistribution at 60 minutes after injection.

	LDLR^–/–ApoB^100/100 ()	C57BL/6N ()	value	LDLR^–/–ApoB^100/100, block ()	value
Adrenal gland	20.79 ± 5.08	33.87 ± 5.24	0.001	4.12 ± 2.12	0.001
Aorta	2.03 ± 0.45	2.52 ± 0.40		1.37 ± 0.20
BAT	0.84 ± 0.25	0.56 ± 0.18		3.37 ± 0.49	<0.001
Blood	0.23 ± 0.05	0.16 ± 0.02	0.046	0.38 ± 0.08	0.001
Bone	0.99 ± 0.26	0.88 ± 0.18		0.75 ± 0.19
Brain	0.48 ± 0.05	0.51 ± 0.07		0.31 ± 0.05	0.004
Intestine	6.13 ± 1.44	5.76 ± 1.21		3.14 ± 1.50	0.017
Kidney	15.71 ± 10.27	9.97 ± 3.32		2.53 ± 0.29	0.037
Liver	3.20 ± 0.71	5.14 ± 1.07	0.005	2.50 ± 0.68
Lung	13.93 ± 9.21	9.85 ± 3.14		2.55 ± 0.74	0.046
Muscle	0.35 ± 0.09	0.38 ± 0.05		0.32 ± 0.02
Myocardium	2.54 ± 0.47	2.31 ± 0.34		0.71 ± 0.13	<0.001
Pancreas	3.07 ± 0.69	2.46 ± 0.44		0.80 ± 0.11	<0.001
Spleen	6.85 ± 3.44	6.48 ± 2.11		1.94 ± 0.53	0.039
Thymus	1.36 ± 0.39	2.03 ± 0.37	0.011	1.42 ± 0.13
Urine	0.14 ± 0.06	0.20 ± 0.14		3.61 ± 2.60	0.001
WAT	0.22 ± 0.19	0.14 ± 0.09		0.36 ± 0.09

The results are expressed as standardized uptake values ± standard deviation. values are derived from ANOVA with Dunnett’s correction, LDLR^–/–ApoB^100/100 mice as the control group. Blank cell in column indicates insignificant value (>0.05). Block: excess amount of nonradioactive GE-180 given intravenously 5 minutes before administration of ¹⁸F-GE-180.