Contrast-Enhanced Magnetic Resonance Angiography Using a Novel Elastin-Specific Molecular Probe in an Experimental Animal Model

Figure 1

Example of a first-pass MR angiography (TWIST) following the administration of the elastin-specific molecular agent and the clinically used gadobutrol. (a, b) The images show the first-pass MR angiography (TWIST) following the administration of the elastin agent and the clinically used agent gadobutrol. (a1, b1) Precontrast images at the level of the heart show no relevant signal enhancement prior to the administration of the probes. (a2, b2) Immediately after the administration of the imaging agents, a high signal in the left and right ventricle can be appreciated during the first-pass. Visually, the signal intensity from both probes was comparable. (a3, b3) 30 seconds after the administration of the probes, a clear reduction of the signal at the level of the heart can be appreciated. (a4, b4) 60 seconds following the administration of the probes, a further decrease in signal can be appreciated. RV: right ventricle; LV: left ventricle.