Multimodality Molecular Imaging-Guided Tumor Border Delineation and Photothermal Therapy Analysis Based on Graphene Oxide-Conjugated Gold Nanoparticles Chelated with Gd

Figure 7

(a) MRI image of GO-AuNS-DOTA-Gd on the coronal plane in the tumor regions on 1st h postinjection; (b) photoacoustic signal distribution of GO-AuNS-DOTA-Gd in the tumor regions on 1st h postinjection; (c) handheld photoacoustic imaging-guided photothermal therapy; (d) and (e) are mice image before treatment, treatment, and after irradiation of PBS group and probe group with handheld PAI guidance; (f) bioluminescence image of mice from probe with PAI guidance, PBS group, and probe without PAI guidance; (g) ¹⁸F-FDG PET image of liver orthotopic tumor-bearing mouse and normal mouse; (h) H&E staining of tumors posttreatment from control group and probe group.