Prognostic Significance of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Anal Squamous Cell Carcinoma: A Systematic Review and a Meta-Analysis

Table 1

Characteristics of selected studies included in the meta-analysis.

First author	Year of publication	Patient source	Number of patients	Median age (range), years	Gender (male/female)	TNM staging	Study design
Schwarz et al. [24]	2008	USA	53	52 (30–89)	20/33	6 stage I, 34 stage II, 8 stage IIIA, and 5 stage IIIB	P
De Winton et al. [16]	2009	Australia	61	57 (27–88)	27/34	19 stage I, 16 stage II, 5 stage IIIA, 19 stage IIIB, and 2 stage IV	P
Mai et al. [23]	2009	Germany	39	59 (37–86)	17/22	9 T1, 21 T2, 5 T3, 4T4, 28 N0, 8 N1, 3 N2	P
Kidd et al. [22]	2010	USA	77^§	53 (30–89)	33/44	2 stage 0, 7 stage I, 49 stage II, 10 stage IIIA, 9 stage IIIB	P
Day et al. [15]	2011	Australia	48	56 (35–87)	22/26	8 stage I, 18 stage II, 6 stage IIIA, 14 stage IIIB, and 2 stage IV	R
Goldman et al. [19]	2016	USA	148	60 (33–91)	44/104	6 stage I, 64 stage II, 21 stage IIIA, and 58 stage IIIB	R
Deantonio et al. [17]	2016	Italy	55^Ψ	67 (44–90)	18/38	4 stage I, 25 stage II, 4 stage IIIA, and 22 stage IIIB	P
Gauthé et al. [18]	2017	France	75	63.8 ± 9.9 (40–88)	8/67	5 stage I, 22 stage II, 20 stage IIIA, and 28 stage IIIB	R
Cardenas et al. [14]	2017	USA	110	54.5^€	48/62	15 stage I, 47 stage II, 48 stage III	R
Houard et al. [21]	2017	France	87	62 (35–89)	19/68	9 T1, 34 T2, 17 T3, 27 T4, 37 N0, 50N+	R
Hong et al. [20]	2018	USA	23	60.1^€	5/18	3 T1, 8 T2, 9 T3, 3 T4, 13 N0, 10N+	P

The study included 41 cases of squamous cell carcinoma, 8 cases of basaloid carcinoma, 2 cases of adenocarcinoma, 1 case of small cell carcinoma, and 1 case of adenosquamous carcinoma. ^§The study comprised 65 cases of squamous cell carcinoma, 11 cases of basaloid carcinoma, and 1 case of small cell carcinoma. ^ΨThe study included 44 cases of squamous cell carcinoma, 3 cases of adenocarcinoma, and 8 cases of cloacogenic carcinoma. ^€Mean age. P, prospective; R, retrospective.