A Comparative ⁶⁸Ga-Citrate and ⁶⁸Ga-Chloride PET/CT Imaging of Staphylococcus aureus Osteomyelitis in the Rat Tibia

Figure 2

Histological sections of osteomyelitic (a) and control (b) rat tibias at 2 weeks after surgery. The osteomyelitic changes were characterised by a wide circumferential periosteal reaction, focally enlarged haversian canals filled with fragmented polymorphonuclear leukocytes and occasional microabscesses, and major infiltration of the bone marrow by polymorphonuclear leukocytes. In some cases, a devitalized bone fragment was seen in the unhealed cortical window. In the control animals, periosteal reaction was minimal and there was modest endosteal new bone close to the cortical defect, indicating healing of the cortical defect. Modified van Gieson stain at ×10 magnification.

(a)

(b)