Sequential [¹⁸F]FDG-[¹⁸F]FMISO PET and Multiparametric MRI at 3T for Insights into Breast Cancer Heterogeneity and Correlation with Patient Outcomes: First Clinical Experience

Figure 2

Graph showing numeric and color-coded Person’s correlation coefficients of all imaging and clinical parameters. Statistically significant correlations are color-coded (blue for negative correlations and green for positive correlations). values are presented in the bottom right corner of each cell (green for significance at the 0.05 level (2-tailed) and red for that at the 0.01 level). The statistically significant correlations ranged from moderate to strong. Abbreviations: T2w, T2-weighted magnetic resonance imaging (MRI); ADC, apparent diffusion coefficient; TIRM, turbo inversion recovery magnitude MRI; DCE, dynamic contrast enhanced MRI; IE, initial enhancement ratio; WO, washout ratio; FMISO/FDG_mean, region of interest mean standard uptake value (SUV) of [¹⁸F]fluoromisonidazole or ¹⁸[F]fluoro-deoxy-glucose; FMISO/FDG_max, region of interest maximum SUV of FMISO or FDG; TBR_mean/_max, tumor to background ratio based on mean/max SUV in the tumor normalized to mean SUV in the aorta; Ki67, proliferation rate; Her2, human epidermal growth factor receptor 2; ER, estrogen receptor; PR, progesterone receptor; Mets, metastasis.