Contrast Media & Molecular Imaging / 2019 / Article / Fig 2

Review Article

A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease

Figure 2

Micropositron emission tomographic image of 9-(4-[18F]fluoro-3-[hydroxymethyl]butyl)guanine ([18F]FHBG) activity in a herpes simplex virus thymidine kinase (HSV-tk) reporter mice after smoke inhalation injury. [18F]FHBG activity is proportional to nuclear factor-kappa B (NF-κB)-mediated gene expression. The arrow indicates the location of the lungs. Note increased pulmonary NF-κB activation, and hence HSV-tk expression, at 24 and 48 hours after smoke inhalation. Reproduced from Syrkina et al. (Reference [35]).

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