A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease

Figure 2

Micropositron emission tomographic image of 9-(4-[¹⁸F]fluoro-3-[hydroxymethyl]butyl)guanine ([¹⁸F]FHBG) activity in a herpes simplex virus thymidine kinase (HSV-tk) reporter mice after smoke inhalation injury. [¹⁸F]FHBG activity is proportional to nuclear factor-kappa B (NF-κB)-mediated gene expression. The arrow indicates the location of the lungs. Note increased pulmonary NF-κB activation, and hence HSV-tk expression, at 24 and 48 hours after smoke inhalation. Reproduced from Syrkina et al. (Reference [35]).