Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with ⁹⁰Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI

Figure 5

IVIM evaluation results for D (a, b), f (c, d), and (e, f) and the three classes of lesions (light grey: regressive; dark grey: stable; red: progressive). The bar plots in (a, c, e) show the values obtained before the initiation of the treatment (T₁), while graphs in (b, d, f) show the evaluation of the values over time (from T₁ to T₄). Note the analogous behavior of D as compared with the ADC values displayed in Figure 3. A statistically significant difference is seen only for D when comparing regressive vs. progressive lesions at T₁ (asterisk; ).

(a)

(b)

(c)

(d)

(e)

(f)